Glutathione Wikipedia The science behind hangovers The site of detoxification in your body is located in your liver. Everything that you ingest is broken down in your digestive system to become small enough Alcohol Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review Your liver needs time to turn ethanol into acetate. If you drink too fast, that "hangover chemical" (acetaldehyde) piles up and ruins the fun. Drink slow and give your enzymes a break.